Climate change has affected most of the world with an increase in indoor molds due to flooding, hurricanes, etc. Diseases associated with molds and mycotoxins are called “The Great Masquerader of the 21st century” by the World Health Organization. There have been a number of recent studies published on how mycotoxins trigger autoimmunity and that the treatment is directed at getting rid of mycotoxins and not treating the autoimmunity. Included in this presentation will be before and after photos and labs of actual patients, including patients diagnosed with Alzheimer’s disease and other neurodegenerative conditions. Mast Cell Activation Syndrome is an emerging disorder and has recently been detected in a number of patients exposed to mycotoxins. Actual patient medical histories, before and after photos and labs are presented. There are some diagnostic studies and treatments that have recently been shown as not helpful in the diagnosis and treatment of mold/mycotoxin patients. These are reviewed.